Three things to consider before choosing an endotoxin detection method: the type of sample to be tested, its interference characteristics, and the endotoxin limit that you want to detect. The Gel-clot method is the simplest and most widely used method for endotoxin detection, and its sensitivity is up to 0.03 EU/ml. The Chromogenic method defines its sensitivity to be the lowest endotoxin concentration in the standard curve and requires a spectrophotometric instrumentation to read the results.