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In order to get the antibody specific to target protein with {Lys(me3)}, can you use peptide with {Lys(me3)} for immunization and use {Lys(me2)} & {Lys(me)} & non-modified peptide for cross adsorption (pAb) or counter screening (mAb)?

In theory, we can. However, since the structure of {Lys(me2)}, {Lys(me)} and {Lys(me3)} are very similar, the project will be really hard. We usually recommend such kind of project to be quoted as customized mab and there will be quite a few antibody left after cross adsorption with 3 peptides.